E. G. Daily

Tommy Pickles (voice)

Christine Cavanaugh

Chuckie Finster (voice)

Cheryl Chase

Angelica Pickles (voice)

Susan Sarandon

Coco LaBouche (voice)

John Lithgow

Jean-Claude (voice)

Tara Strong

Dil Pickles (voice)

Kath Soucie

Lil Deville / Phil DeVille / Betty DeVille (voice)

Michael Bell

Drew Pickles / Chaz Finster, Sr. (voice)

Cree Summer

Susie Carmichael (voice)

Tress MacNeille

Charlotte Pickles (voice)

Debbie Reynolds

Lulu Pickles (voice)

Joe Alaskey

Grandpa Lou Pickles (voice)